Cannabinoid receptors in GtoPdb v.2023.1

Cannabinoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [119]) are activated endogenous ligands that include N-arachidonoylethanolamine (anandamide), N-homo-γ-linolenoylethanolamine, N-docosatetra-7,10,13,16-enoylethanolamine and 2-arachidonoylglycerol. Potency determinations of agonists at these complicated possibility differential susceptibility to enzymatic conversion [5].There currently three licenced cannabinoid medicines each which contains a compound can activate CB1 CB2 [111]. Two were developed suppress nausea vomiting produced chemotherapy. These nabilone (Cesamet®), synthetic CB1/CB2 receptor agonist, Δ9-tetrahydrocannabinol (Marinol®; dronabinol), also be used an appetite stimulant. The third medicine, Sativex®, mainly cannabidiol, both extracted from cannabis, is treat multiple sclerosis cancer pain.